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Tell your prescribing doctor if you have any of these conditions, which can increase B12 shot side effects: An allergy to cobalt Kidney disease Severe megaloblastic anemia Side Effects from B12 Shots The most common B12 shot side effect is swelling at the injection site

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consequently, the speed at which it takes effect is closely correlated with factors such as dosage, route of administration, and the individual's level of neural plasticity