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Although cigarette smoke is very complex, consisting of over 4,000 compounds linked to CVD, most studies suggest that carbon monoxide, reactive oxygen species, and nicotine are responsible for the pathogenesis of smoking-induced cardiovascular disorders ( 10 , 11 )

In addition, it discusses additional efficacy endpoints that may be used in NRT drug products that have already demonstrated effectiveness in smoking cessation or reduction of risk of relapse: reduction in urge to smoke, relief of cue-induced craving in former smokers, and relief of withdrawal symptoms not associated with a cessation attempt

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