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There are currently lawsuits pending in California by three men who claim their e-cigarettes had exploded while they were using them

Esophageal Muscles : As with the lower esophageal sphincter, nicotine can also relax the smooth muscle that lines the entire length of the esophagus

The American Lung Association stated that without FDA regulation, there is no way for the public health and medical community or consumers to know what chemicals are contained in e-cigarettes or what the short and long-term health implications might be.

A recent study identified deleterious changes in the left ventricular structure leading to cardiovascular dysfunction and increased systemic arterial resistance [96]