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No randomized human trial has established a clinically validated dose all protocols derive from animal data and clinician case series, principally the Sikiric et al

Calculate your dose and schedule Map the trial titration protocol onto a calendar: enter a start date and a target dose level to see the week-by-week escalation, the units to draw at each step, and what to expect and watch for along the way

Excess visceral fat leads to increased production of pro-inflammatory cytokines, including TNF-, IL-6, and IL-17, as well as the following adipokines: leptin, visfatin, and resistin, which exacerbate inflammation (13, 205)

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