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Patient fibroblasts from a skin punch biopsy can be used to create iPSC lines 48 , which are then differentiated into BBB-related cell types, including neurons, microglia, endothelial cells, vascular smooth muscle cells, and vascular pericytes 62,63,64

In our present follow-up study, we synthetized non-targeted and A-GSH functionalized 3-PLG nanoformulations coupled with dopamine and ibuprofen as active agents

The treatments included EGCG-Zn nanocomposite suppositories (100/25 mg/kg), EGCG (100 mg/kg), Zn (25 mg/kg), a physical mixture of EGCG and Zn (100/25 mg/kg), and a blank suppository base