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The adoption of the PCPA-induced insomnia model in mice has enabled researchers to delve into the molecular mechanisms underlying sleep regulation ( GABA (Gamma-Aminobutyric Acid) primarily functions as an inhibitory neurotransmitter in the brain, promoting relaxation and sleep (Yoto et al., 2012

(4) Sample size differences: The referenced studies included 430 and 130 subjects, respectively, compared to the 6,180 individuals analyzed in this study [13, 14]

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Exploring the In Vivo Effects of Metformin and Simvastatin in Regulating the Malignant Progression of Glioblastoma After treating mice with metformin and simvastatin according to the standard intracranial xenograft procedure, the tumor volume significantly reduced compared to the untreated control group (Fig