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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Common Side Effects Nausea (typically improves after 2-4 weeks) Diarrhea or constipation Decreased appetite (this is the goal) Mild stomach discomfort Fatigue during dose increases When to Call Your Doctor Severe or persistent nausea/vomiting Signs of pancreatitis (severe abdominal pain) Vision changes Rapid heartbeat Signs of allergic reaction Is Semaglutide Right for You

People who are pregnant or breastfeeding need to talk with their doctor first