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The Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE) study demonstrated significant improvement in renal outcomes with canagliflozin in patients with T2DM and advanced macro-albuminuric kidney disease, as compared to placebo [63]

Reductions in HbA 1c and body weight from baseline to week 26 in the overall PIONEER 12 population were greater than those observed at week 26 in the PIONEER 3 trial, which assessed oral semaglutide 3 mg, 7 mg and 14 mg vs sitagliptin 100 mg in a global population across 78 weeks [18]

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In animal experimental studies (necropsy findings) pancreas related acute or chronic diseases were described as side-effects of GLP-1RA