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doi: 10.1007/s00726-009-0334-8 57 TanK.ZhangH.LimL.-S.MaH.LiS.ZhengH

Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment

A summary of approximate phases, based on trial data, is as follows: Weeks 14: Appetite suppression and early metabolic changes may begin Weeks 412: Noticeable weight loss may commence Weeks 1248+: Progressive weight reduction, continuing through the trial period at higher doses These timelines reflect phase 2 trial experience and may differ in real-world settings