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Nuclear factor erythroid 2-related factor 2 plays a fundamental role in the response to oxidative stress and xenobiotic metabolism and detoxification, and the Nrf2 signaling pathway is intimately associated with development of atherosclerosis

A limitation of this study was the activation of heterogenous NTS neuron populations (i.e., Neither GLP-1-producing cells or projection-specific neurons were targeted)

Potentially fatal conditions associated with tirzepatide include thyroid tumors and thyroid cancer, acute kidney injury and gastroparesis (stomach paralysis)

The most common side effects of tirzepatide are gastrointestinal in nature, including nausea, constipation, and occasional diarrhea, and these typically improve as the body adjusts during the early weeks of dose titration