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Smoke from fire damage can be even more illusive and stubborn than smoke from tobacco products

Sampaiozyma secretes a variety of enzymes to targetedly decompose macromolecular substances in tobacco leaves while producing key aroma precursors, which contributes to the maturation of tobacco leaves

Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig

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