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Full anti-aging benefits may take 3-6 months to develop

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In clinical applications, numerous natural compounds, acting as endogenous activators of NRF2, demonstrate significant potential in alleviating intestinal disorders by promoting nuclear translocation and the expression of downstream antioxidant and anti-ferroptotic genes ( Uncontrolled lipid peroxidation is a hallmark of ferroptosis, with Acyl-CoA synthetase long-chain family member 4 (ACSL4) playing a central regulatory role in this process

simultaneously, it elicits secondary ER-agonist effects in bone, preventing osteoporosis, but also acts as an agonist in the uterus, leading to an increased risk of endometrial cancer (Rachner et al., 2018