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Participants took a single oral dose of metoprolol, waited a one-week washout, then received subcutaneous retatrutide followed by a second oral dose of metoprolol

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Two active proteins from rattlesnake venom

The most commonly mentioned effects include mild nausea in some users (typically transient), injection site reactions (redness, minor discomfort), mild headache or dizziness (uncommon), and sleep disruption with late-day dosing (reported by some users)