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It is now widely accepted that oxidative stress can lead to changes in the expression of specific genes including renal injury-related genes, like kidney injury molecule 1 (KIM-1), tumor necrosis factor alpha (TNF-), and Neutrophil gelatinase-associated lipocalin protein (NGAL) [15]
CD154 induces matrix metalloproteinase-9 secretion in human podocytes
doi: 10.1242/jeb.155465 95 RostamiRAghasiMRMohammadiANourooz-ZadehJ
There may also be dose-related effects and other modifiable factors that play into patient preferences in considering changing or stopping medication
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