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We further examine emerging therapeutic strategies aimed at restoring zinc homeostasis, including supplementation and bioengineered, organelle-targeted delivery systems, as well as advanced tools for visualizing zinc dynamics at subcellular resolution

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This Erastin-induced increase in autophagic flux is crucial because it directly enables ferritinophagy, a selective process that targets the iron-storage protein ferritin for degradation and is now recognized as a key driver of ferroptosis

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