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Users say that they arent as hungry on the drug
Bupropion XL, which includes Forfivo XL at the 450 mg strength, is once daily and usually what physicians reach for when they want simplicity and consistency
### The STEP 5 Study: Long-Term Adherence The STEP 5 two-year extension study (*Nature Medicine*, 2022) showed: - Patients who maintained consistent dosing for 2 years sustained an average weight loss of 15.2% - Adherence was the strongest predictor of long-term success - Patients who missed occasional doses (but did not discontinue) still achieved meaningful results - The difference between "perfect" adherence and "good" adherence (missing 12 doses per quarter) was relatively small **Key takeaway**: Don't panic about occasional missed doses
Competitor data indicates that patients typically lose 5% of their initial body weight on average, and this can increase to over 10% within three months of use
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