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Specifically, it has been shown that lactate uptake by cancer cells alters the NAD + /NADH ratio, followed by sirtuin (SIRT)1-dependent peroxisome proliferator-activated receptor gamma coactivator (PGC)-1 activation and subsequent increase of mitochondrial mass and activity

On the other hand, IRPs combine with the IRE on the transferrin receptor mRNA to stabilize its mRNA, promote the expression of transferrin receptor, and increase iron uptake (Recalcati et al., 2010

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