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Description

"Although half of the mutations that cause Ehlers-Danlos syndrome types I and II are likely to affect the COL5A1 gene, a significant portion of the mutations result in low levels of mRNA from the mutant allele as a consequence of nonsense-mediated mRNA decay." [2] [11] Kyphoscoliotic (type VI) is characterized by generalized joint laxity, skin fragility, and severe muscle hypotonia at birth

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Cell Biol Toxicol 16(6):347362

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Connectivity Map (CMap) A database developed at the Broad Institute (MIT/Harvard) that maps how thousands of compounds alter gene activity across the human genome

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It has also shown efficacy in managing conditions such as chronic fatigue syndrome, autism, and HIV/AIDS

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