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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides

Genetic studies using DHAR overexpression, knockdown, and/or knockout lines supported the physiological importance of DHARs in ascorbate recycling (Chen et al

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