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Funding This work was supported by the Science and Technology Plan Joint Program of Liaoning Province [Grant No.2023JH2/101700148 to PQ], National Natural Science foundation of China [Grant No.82103468 to YL], Natural Science foundation of Liaoning Province of China [Grant No.2020-MS-178 to XG] and 345 Talent Project of Shengjing Hospital of China Medical University [M0961 to YL]

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