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Localized instillation enables in vivo screening of targeting peptides using one-bead one-compound technology

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Next, we constructed the atherosclerotic microenvironment-responsive protein nanoassembly by reversibly cross-linking Mn@mHSA and TI@mHSA using a ROS-responsive cross-linker, bis-N-hydroxy succinimide modified 2,2-[propane-2,2-diylbis(thio)]diacetic acid (NHS-TK-NHS)

In other embodiments, when an even more viscous medium is desired, the biocompatible gel comprises at least about 35%, at least about 45%, at least about 55%, at least about 65%, at least about 70%, at least about 75%, or even at least about 80% or so by weight of the active agent