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Mutant receptors were then screened for their capacity to undergo exendin-4-induced internalisation, as this GLP-1R property is severely inhibited following cholesterol extraction with MCD (31)

(And even if they were approved, pharmaceutical companies would shy away from them for fear of being undercut by compounding pharmacies.) If companies can sell them and make lots of money without having to prove that they do what theyre claimed to do, why wouldnt they? Zettler points out

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Cellular aggregation ESR (Westergren tubes or automated)