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Causes Primary Adrenal Insufficiency (Addison's Disease) autoimmune diseases ( most common cause - 80% ) - approximately 50% of patients with autoimmune adrenal insufficiency have one or more other autoimmune endocrine disorders, whereas patients with the more common autoimmune endocrine disorders, such as type 1 diabetes mellitus, Hashimoto's autoimmune thyroiditis, or Graves' disease, rarely develop adrenal insufficiency

Heart involvement such as palpitations, irregular heartbeat, or a condition called Lyme carditis wherein the bacteria disrupts the electrical system of the web

Coskun T, Heise T, DeVries J et al (2022) Tirzepatide reduces appetite, energy intake and fat mass in people with type 2 diabetes