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Navigation of dietary preferences and intakes GLP-1s meaningfully impact total energy intake and food preferences through multiple mechanismsan active area of investigationincluding peripherally in the gut, centrally in multiple brain regions, and through diet-microbiomebrain interactions [142]

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Topiramate should be considered in younger children not responding to lifestyle interventions alone with poor satiation, food cravings, binge eating, psychotropic medication-induced obesity, migraine headaches, night eating (when dosed at night), seizure disorder, idiopathic intracranial hypertension, severe non-verbal autism, or mood lability