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The GLP-1R is part of the glucagon family of receptors, including the glucose-dependent insulinotropic polypeptide receptor (GIPR) (5), the glucagon receptor (GCGR) (12), and the glucagon-like peptide-2 receptor (GLP-2R) (13), which are class B1/secretin-like G protein-coupled receptors (GPCRs) with a typical structure of seven transmembrane domains (7-TMD), a C-terminal tail, and a large N-terminal extracellular domain (ECD) important for peptide agonist binding (14)

The prevalence of obesity among children and adolescents has increased globally in recent decades

It suppresses appetite, stimulates insulin release, and promotes fat breakdown in the body

What is Hormone Replacement Therapy (HRT)