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Rybelsus by Novo Nordisk, which is used for Type 2 diabetes, was the first oral medication to reach the market

Endocrinology (2016) 157:395871

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The Effects of Metformin and Simvastatin on the Proliferation and Apoptosis of glioma Cells After 48 h of treatment with low doses of metformin, simvastatin, and their combination, it was observed that the combined treatment had a higher inhibitory effect on the proliferation of U87, LN229, T98G, and U251 glioblastoma cells compared to individual treatments with metformin or simvastatin alone