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Some patients can maintain their weight without medication, while others may need a low maintenance dose to help control food noise, cravings, or weight regain

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In a study of more than 240,000 people, heavier individuals were significantly more likely to form stones than lean ones.[3] The reason is biochemical: obesity and insulin resistance push the kidney to excrete more calcium, oxalate, and uric acid, and they make the urine more acidic close to a perfect recipe for stone crystals

The relative abundance of Erysipelatoclostridium was increased in vehicle-treated mice that underwent the WD to LD switch (WD/LD-V) relative to the two control groups (LD/LD-V and WD/WD-V) but was not increased in 5A-1MQ-treated mice that underwent the same diet switch (WD/LD-T)