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If the treatment causes a detrimental shift in microbial composition, leading to adverse effects like gastrointestinal distress or immune suppression, healthcare providers could intervene by adjusting the treatment regimen or introducing probiotic interventions to restore microbial balance
On the other hand, the dual GLP-1-glucose-dependent insulinotropic peptide (GIP) receptor agonist LY3298176 (Tirzepatide) provided substantial and sustained reductions in body weight in a 72-week trial in individuals with obesity 19
Prevalence The incidence of pernicious anaemia is uncertain but international studies have estimated it to be 0.1% among the general population, rising to 1.9% in those aged over 60 years
In addition to strictly controlling blood glucose, its treatment should also start from other ways, explore more effective and specific treatment schemes for various causes of DPN, and find new targets for treatment will be the direction of developing DPN therapeutic drugs in the future
