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Interestingly, male patients with inflammatory bowel disease (IBD) exhibit downregulated GPER expression in intestinal tissue, accompanied by elevated proinflammatory cytokine levels, whereas female patients are more likely to benefit from GPER agonists, which increase anti-inflammatory signaling and reduce intestinal inflammation [76]
The suppressor protein p53 is associated with delays in cell cycle progression at G1, reducing the speed of cell proliferation (Khan & Wang, 2022)
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