In the Caco-2 cell monolayer model, the Papp values of many other natural products, such as paeoniflorin, liquiritin, dammarane saponins and ginsenoside, were less than 1 10 6 cm/s according to literature
Immunosuppressive agents with intrinsic antifungal activity are emerging as candidates for drug repurposing, including calcineurin inhibitors (e.g., cyclosporine, pimecrolimus, tacrolimus/FK506), mTOR inhibitors (e.g., rapamycin), antimetabolites (e.g., mizoribine [MZP], mycophenolic acid [MPA]), and glucocorticoids
PMID 9050227
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