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Psychiatry 76 , 970976 (2014)

Average 15-20% body weight loss Clinical trials show participants lost 15.2% of body weight over 68 weeks with GLP-1 2.4mg weekly

GLP-1 Receptor Agonists (GLP-1 RAs):Primary mechanism: Mimicking the GLP-1 hormone to regulate appetite, blood sugar, and potentially influencing brain reward pathways.Common side effects: Nausea, vomiting, diarrhea, constipation (often gastrointestinal).Potential benefits for mood: Indirect effects through weight management, reduced "food noise," and possible anti-inflammatory actions

[PubMed] [PMC] Duval C, Teixeira-Clerc F, Leblanc AF, Touch S, Emond C, Guerre-Millo M, Lotersztajn S, Barouki R, Aggerbeck M, Coumoul X (2017) Chronic exposure to low doses of dioxin promotes liver fibrosis development in the C57BL/6J diet-induced obesity mouse model