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Jun 2020;53(3):385-395

Other mechanisms explaining the effects of metformin on thyroid cell growth and viability are the downregulation of cyclin D1, the increase of the ER stress and the reduction of mRNA levels of AKT, PI3K, and FOXO1 LRP2 and p-JNK, genes that play a crucial role in cell proliferation and survival (Oyadomari and Mori, 2004

As the peptide is enzymatically cleaved, the copper ion is released and either incorporated into newly synthesized copper-dependent enzymes or chelated by albumin for redistribution

Oxidative stress can lead to carcinogenesis through its ability to alter genetic material (DNA), affect cellular signalling pathways and cell cycle regulation, promote angiogenesis and metastasis