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Clinical studies have shown that liver cirrhosis patients treated with long-term -blockers exhibit a significant increase in intracellular cAMP levels under adrenergic stimulation, suggesting that chronic -blocker therapy restores -adrenergic receptor responsiveness to catecholamine stimulation 72

Agilent, 10376-100) supplemented with 2 mM glutamine (Thermo Fisher Scientific, 25030081) and 10 mM glucose (Thermo Fisher Scientific, A2494001)