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Since this feature appears to be typical for Central regions of the European part of Russia and is associated with fluctuations in atmospheric pressure and climatic changes, this will require further validation in other samples from other latitudes to determine the validity of this measure in the general population

These findings indicate the presence of an inflammatory feature in CHL and the hyperactivation of both adaptive and innate immune pathways in the host bile environment

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All opinions and descriptions are based on preclinical research, publicly available information, and the company's published materials