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Rotate sites and ensure proper injection technique to minimize this

In a classic study of an entire community, Tunbridge et al.(37) found that 1.9 - 2.7% of women had present or past thyrotoxicosis, 1.9% had overt hypothyroidism, 7.5% had elevated TSH levels, 10.3% had test results positive for TPO (microsomal antigen) Ab measured by hemagglutination assay (MCHA), and about 15.0% had goiter

However, there is still a lack of direct evidence for these mechanisms except bile acid metabolism

This discovery provides a novel therapeutic strategy for overcoming breast cancer resistance and restoring sensitivity to estrogen therapy [98]