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Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide ( More recent analyses suggest that spexins metabolic actions may be dissociable from its nociceptive or affective effects through receptor subtype selectivity and dosing strategies ( 4.3 Meteorin-like protein (METRNL) and exercise-induced endocrinology Meteorin-like protein (METRNL) occupies a distinct conceptual niche within metabolic peptide biology

These results suggest that continuing GLP-1RAs has an inhibitory effect on weight regain and that they must be used long-term in treating obesity