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Conversely, venglustat, a glucosylceramide synthase inhibitor, failed to show any clinical benefit over placebo in GBA1-related PD in part 2 of a recent phase 2 trial [126], after having demonstrated favourable safety, tolerability, and target engagement in the cerebrospinal fluid (CSF) in part 1 of the same trial [127]

Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver

In cases refractory to medical management, surgical interventions such as venous sinus stenting [8], optic nerve sheath fenestration (ONSF), and CSF shunting procedures may be necessary [9]

Others might feel it anytime they eat certain foods, especially fatty or rich meals