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Moreover, stressed melanocytes undergo apoptosis and secrete melanocyte-specific antigens and immunostimulatory signals such as cytokines (IL-6 and IL8) (Bettigole and Glimcher, 2015), which attract autoimmune reactions toward melanocytes and cause disease progression (Colucci et al., 2015)

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Zinc deficiency also leads to a decrease in epidermal transforming growth factor (TGF)-1, which in turn reduces the number of epidermal Langerhans cells, another important subset of DCs [267, 268]

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