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Tat (transactivator of transcription) protein, even in the absence of productive infection, can enter mitochondria and inhibit the expression and function of TFAM (Mitochondrial transcription factor A), thereby impairing mtDNA replication and transcription and reducing the expression of mtDNA-encoded ETC subunits (83, 84)

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Zhuge A, Li S, Yuan Y, Han S, Xia J, Wang Q, et al