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Yes, B12 often pairs well with: Folate and B6 (for methylation support) Iron and vitamin C (if youre also iron deficient) NAD+ protocols, creatine, omega-3s, and other performance-focused additions Because B12 can interact with certain medications and medical conditions, discuss your full stack with your healthcare provider

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However, according to the National Institute of Child Health and Human Development, folic acid supplementation reduces the risk of neural tube defects in all pregnant women, including women with an MTHFR variant