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Patients should: Inspect the medication for particulate matter or discoloration before use (solution should be clear to slightly yellow) Allow the pen to reach room temperature (30 minutes out of refrigerator) to reduce injection discomfort Clean the injection site with an alcohol swab and allow to dry Rotate injection sites systematically to prevent lipohypertrophy Inject at a 90-degree angle, holding the pen firmly against the skin Keep the pen pressed against the skin until the injection is complete (about 10 seconds) as indicated by the plunger stopping or the indicator showing completion Never share pens or needles with others, even if the needle has been changed Dispose of used pens in an FDA-cleared sharps container Injections in the upper arm typically require administration by another person