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Studies show that RNAi-induced GPX4 downregulation is sufficient to induce ferroptosis, while GPX4 overexpression in HT-1080 cells confers resistance to ferroptosis, and GPX4-deficient cells are more susceptible (Yang et al., 2014)
Glutathione is a tripeptide made from three amino acids: cysteine, glycine, and glutamic acid
[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Scott P.M., Zhao W., Feng S., Lau B.P.-Y
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