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Although this supposed correlation has a great impact on the mass media, most clinical and epidemiological reports to date have not revealed a causal relationship between growth hormone therapy and as a consequence of an increase in IGF-1 levels and an increased risk of cancer (Werner & Laron., 2020)

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Conversely, mice with parathyroid-specific deletion of the tuberous sclerosis complex-1 gene (Tsc1) leading to mTORC1 hyperactivation, exhibited enlarged parathyroid glands and elevated serum PTH and calcium levels (142)