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Potential TMA-producing bacteria are ubiquitously found in mammalia

In 56.4% of patients, ACR20 response and in 39.74% patients moderate response [European League against Rheumatism (EULAR) criteria] was observed

Fallone CA, Chiba N, van Zanten SV, Fischbach L, Gisbert JP, Hunt RH, Jones NL, Render C, Leontiadis GI, Moayyedi P, Marshall JK (2016) The Toronto consensus for the treatment of Helicobacter pylori infection in adults

25,26 Furthermore, a polymorphism of the DHFR enzyme resulting in a 19bp deletion within the site of a key regulatory sequence has been theorized to exhibit negative effects on the expression and activity of this enzyme