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Description

The role of pharmacists in managing adverse events related to immune checkpoint inhibitor therapy

Risks The majority of instances of PAM are benign

In macrophage cells, -KG produced via glutaminolysis promotes M2 activation via Jmjd3-dependent metabolic and epigenetic reprogramming 108

A change in the regulation of Ca 2+ in lymphocytes disrupts the control of metabolism, proliferation, differentiation, secretion of antibodies, cytokines and cytotoxicity, which leads to autoimmune and inflammation diseases (130)