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For MACE-4, the HR was 0.80 (95% CI, 0.571.11) for tirzepatide versus standard therapy, the HR for cardiovascular death 0.90 (95% CI, 0.501.61) and 0.80 (95% CI, 0.511.25) for all-cause death

Patients Concern Disease/Condition Glossary Macular degeneration: An eye disease that causes vision loss due to a problem with the retina

The study concluded that in newborn rats, the activation of the c-Fos gene worked to increase body weight, while at more advanced ages the treatment led to a decrease in body weight and an increase in uncoupling protein 1

The findings were published in T he Journal of Clinical Endocrinology & Metabolism