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9.6 Probiotics in obesity and cardiometabolic health Among the multiple factors driving the modern escalation of obesity, the most prominent are an inherited genetic susceptibility and a sustained energy imbalance, defined by a chronic excess of caloric intake relative to energy expenditure (412)

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However, as our understanding of cell signaling and regulatory pathways has developed, so has the involvement of GSH homeostasis in many other key processes, including regulation of cell proliferation and apoptosis and post-transcriptional modification of proteins through S-glutathionylation

Once a treatment plan has been implemented, monitoring beta-glucuronidase levels and hormone metabolism is essential to ensure consistently effective interventions