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Drugs (e.g., calcium channel blockers, opiates, antispasmodics, antidepressants) [9] altered autonomic outflow and bowel muscle contraction [10] Endocrine pathology (e.g., hypothyroidism) downregulated bowel motility Neurological pathology (e.g., spinal injury, enteric neuropathy) disease or trauma of bowel innervation Ineffective peristalsis difficult passage of stool regardless of stool consistency sensation of incomplete and irregular bowel emptying References: [10] [11] Approach to management Manage complications Identify and treat fecal impaction

Gunnarson, E

For most people, eye color will not change significantly past infancy

To explore the enhanced dependency on mitochondrial function, we further explored the acute metabolic stress imposed by 5FU treatment