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Their 7-TMD structure involves intimate interactions with plasma membrane lipids (15), known to be non-homogeneously distributed but rather organised in regions known as lipid nanodomains or lipid rafts, enriched in lipid species including sphingolipids and cholesterol, as well as in integral membrane proteins serving as scaffolds for signal transduction (17, 18), and GPCR trafficking and sorting (15, 19, 20)

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This may reflect differences across the studies including the duration of illness, age (in particular, the lower mean age of both healthy controls and MDD patients in the studies of occipital cortex), and medication use

The rapid spread of MDROs highlights the necessity for coordinated actions worldwide to fully scale up policies to use those existing antibiotics more sparingly, develop new antibiotics with new modes of action, and curtail the emergence of such resistant strains