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Solid-Phase Synthesis of Semaglutide: Using Novel Fragment Coupling Strategy to Overcome Aggregation, Improve yield and Quality

This hasnt been confirmed in humans, but dont use semaglutide if you have a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2

The fragment based approach significantly reduced aggregation and process-related impurities, resulting in substantial improvement in yield and purity compared with conventional stepwise peptide elongation protocols, thereby demonstrating an efficient and robust strategy for Semaglutide synthesis